The best is a toad suspended by the legs in a chimney for three days

All knowledge is built on the foundation of those who went before, of whom, Isaac Newton was one of the giants. He lived through the last major plague outbreak in England in 1665 and his curiosity about the source, causes and treatment was aroused and the subject of later reading and research.

Isaac Newton manuscript with toad vomit plague cure for sale by History Blog notes that two pages of his notes from a reading of Tumulus Pestis (“The Tomb of the Plague”) written by Jan Baptist Van Helmont, a Dutch scientist, following his experiences of the 1605 in Antwerp.

Among Newton's notes:

For Zenexton [amulets] against the plague, Hyacynth [might be the stone jacinth?] is a good antidote; sapphire is better; even amber is good; but the best is a toad suspended by the legs in a chimney for three days, which at last vomited up earth with various insects in it, onto a dish of yellow wax, and shortly after died. Combining powdered toad with the excretions and serum made into lozenges and worn about the affected area, drove away the contagion and drew out the poison.

Forget hydroxychloroquine. Has the CDC considered this?

I await a breakthrough treatment.