Geno's Paradox

Geno's Paradox:

Highly heritable traits cannot be associated with common genes of large effect.

In the vernacular, perhaps: Things we know are true but we don't why or how they are true (yet.)

As an example, we know height to be a highly heritable trait but there is no single gene which determines height. Indeed, of the fifteen genes most associated height, collectively they only account for some 2% of the variance in height.


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